Svante paabo biography graphic organizer


Svante Pääbo

Swedish geneticist (born 1955)

Svante PääboForMemRSKmstkNO (Swedish:[ˈsvânːtɛ̂ˈpʰɛ̌ːbʊ̂];[3] born 20 April 1955) is clever Swedish geneticist and Nobel Laureate who specialises in the field of evolutionary genetics.[4] As one of the founders of paleogenetics, he has worked mostly on the Neanderthal genome.[5][6] In 1997, he became founding director of say publicly Department of Genetics at the Feature Planck Institute for Evolutionary Anthropology concern Leipzig, Germany.[7][8][9] Since 1999, he has been an honorary professor at Metropolis University; he currently teaches molecular evolutionary biology at the university.[10][11] He level-headed also an adjunct professor at Campaign Institute of Science and Technology, Japan.[12]

In 2022, he was awarded the Chemist Prize in Physiology or Medicine "for his discoveries concerning the genomes insinuate extinct hominins and human evolution".[13][14][15]

Education ahead early life

Pääbo was born in Stockholm, Sweden, in 1955 and grew preclude there with his mother,[5]Estonian chemist Karin Pääbo (Estonian:[ˈpæːpo]; 1925–2013), who had fleeing from the Soviet invasion in 1944[16] and arrived in Sweden as straight refugee during World War II.[17][18] Take steps was born through an extramarital affair[19] of his father, Swedish biochemist Sune Bergström (1916–2004),[5] who, like his prophet, became a recipient of the Chemist Prize in Physiology or Medicine (in 1982).[20] Pääbo is his mother's child; he has via his father's marriage a half-brother (also born be glad about 1955).[21]

Pääbo grew up as a pick Swedish speaker.[22] In a 2012 question period with the Estonian newspaper Eesti Päevaleht, he said that he self-identifies orang-utan a Swede, but has a "special relationship with Estonia".[23]

In 1975, Pääbo began studying at Uppsala University, serving helpful year in the Swedish Defense Support attached to the School of Interpreters. Pääbo earned his Ph.D. from City University in 1986 for research investigation how the E19 protein of adenoviruses modulates the immune system.[24]

Research and career

Pääbo is known as one of influence founders of paleogenetics, a discipline lapse uses genetics to study early mankind and other ancient species.[25][26]

From 1986 pick up 1987, he did postdoctoral research bequeath the Institute for Molecular Biology II, University of Zurich, Switzerland.[27]

As an EMBO Postdoctoral Fellow, Pääbo moved to illustriousness United States in 1987, accepting keen position as a postdoctoral researcher welloff biochemistry at the University of Calif., Berkeley, where he joined Allan Wilson's lab and worked on the genome of extinct mammals.[27][28]

In 1990, he common to Europe to become professor dead weight general biology at the University reproduce Munich, and, in 1997, he became founding director of the Max Physicist Institute for Evolutionary Anthropology in Metropolis, Germany.[28]

In 1997, Pääbo and colleagues widespread their successful sequencing of Neanderthal mitochondrial DNA (mtDNA), originating from a individual found in Feldhofer grotto in excellence Neander valley.[29][30]

In August 2002, Pääbo's turnoff published findings about the "language gene", FOXP2, which is mutated in heavy individuals with language disabilities.[31]

In 2006, Pääbo announced a plan to reconstruct interpretation entire genome of Neanderthals. In 2007, he was named one of Time magazine's 100 most influential people near the year.[32]

In February 2009, at rectitude Annual Meeting of the American Interact for the Advancement of Science (AAAS) in Chicago, it was announced lose concentration the Max Planck Institute for Evolutionary Anthropology had completed the first rough draft version of the Neanderthal genome.[33] Study 3 billion base pairs were sequenced manifestation collaboration with the 454 Life Sciences Corporation.[34]

In March 2010, Pääbo and rule coworkers published a report about significance DNA analysis of a finger thirsty found in the Denisova Cave tension Siberia; the results suggest that rectitude bone belonged to an extinct contributor of the genusHomo that had sound yet been recognised, the Denisova hominin.[35] Pääbo first wanted to classify depiction Denisovans as a species of their own, separate from modern humans contemporary Neanderthals but changed his mind aft peer-review.[36][37]

Pääbo's doctoral student Viviane Slon was able to successfully map the Denisovan genome, clarifying geographic distribution and admixtures in archaic humans.[38][39]

In May 2010, Pääbo and his colleagues published a outline sequence of the Neanderthal genome meticulous the journal Science.[40] He and fillet team also concluded that there was probably interbreeding between Neanderthals and Eurasiatic (but not Sub-Saharan African) humans.[41] At hand is general mainstream support in rendering scientific community for this theory well interbreeding between archaic and modern humans.[42] This admixture of modern human become calm Neanderthal genes is estimated to imitate occurred roughly between 50,000 and 60,000 years ago, in the Middle East.[43]

In 2014, he published the book Neanderthal Man: In Search of Lost Genomes where he, in the mixed crumb of a memoir and popular discipline art, tells the story of the proof effort to map the Neanderthal genome combined with his thoughts on in the flesh evolution.[20][44]

In 2020, Hugo Zeberg and Svante Pääbo determined that more severe impacts upon victims of the COVID-19 ailment, including the vulnerability to it limit the incidence of the necessity archetypal hospitalisation, have been associated via Polymer analysis to be expressed in ethnological variants at chromosomal region 3, world power that are associated with European Oafish heritage. That structure imposes greater deliberation that those affected will develop spruce up more severe form of the disease.[45] The findings were described in splendid Nature article with Hugo Zeberg differ Karolinska Institutet and Svante Pääbo evade the Max Planck Institute.[45]

As of October 2022[update], Pääbo has an h-index of 167 according to Google Scholar[4] and disparage 133 according to Scopus.[46]

Awards and honours

In 1992, he received the Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft, which is the highest honour awarded in German research. Pääbo was first-rate a member of the Royal Norse Academy of Sciences in 2000, swallow in 2004 was elected an worldwide member of the National Academy allowance Sciences.[47] In 2005, he received prestige prestigious Louis-Jeantet Prize for Medicine.[1] Unexciting 2008, Pääbo was added to birth members of the Order Pour develop Mérite for Sciences and Arts. Hem in the same year, he received prestige Golden Plate Award of the Inhabitant Academy of Achievement.[48] In October 2009, the Foundation For the Future declared that Pääbo had been awarded say publicly 2009 Kistler Prize for his be anxious isolating and sequencing ancient DNA, procedure in 1984 with a 2,400-year-old mummy.[49] In June 2010, the Federation leave undone European Biochemical Societies (FEBS) awarded him the Theodor Bücher Medal for left achievements in Biochemistry and Molecular Biology.[50] In 2013, he received Gruber Reward in Genetics for groundbreaking research unsubtle evolutionary genetics.[51] In 2014, Pääbo was awarded the Swedish sv:Learning Ladder Guerdon. In June 2015, he was awarded the degree of DSc (honoris causa) at NUI Galway.[52] He was select a Foreign Member of the Princely Society in 2016,[2] and in 2017, was awarded the Dan David Accolade. In 2018, he received the Monarch of Asturias Awards in the class of Scientific Research and the Körber European Science Prize[53], in 2020 distinction Japan Prize,[54] in 2021 the Massry Prize[55] and in 2022 the Altruist Prize in Physiology or Medicine[56] summon sequencing the first Neanderthal genome.[14]

Personal life

Pääbo wrote in his 2014 book Neanderthal Man: In Search of Lost Genomes that he is bisexual. He taken he was gay until he reduce Linda Vigilant, an American primatologist celebrated geneticist whose "boyish charms" attracted him. They have co-authored many papers, act married and raising a son skull a daughter together in Leipzig.[57][6]

Distinctions

See also

References

  1. ^ ab"Professor Svante PÄÄBO | Jeantet". 1 October 2017. Archived from the another on 16 May 2021. Retrieved 16 October 2021.
  2. ^ ab"Svante Paabo". London: Regal Society. 2016. Archived from the modern on 29 April 2016. One guts more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the denomination 'Biography' on Fellow profile pages decline available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, situation and policies". Archived from the inspired on 25 September 2015. Retrieved 9 March 2016.

  3. ^Lena Nordlund, Annlouise Martin (Producers) (14 August 2014). Svante Pääbo(MP3) (Radio). Sveriges Radio. Event occurs at 1:15. Archived from the original on 3 October 2022. Retrieved 2 May 2018.
  4. ^ abSvante Pääbo publications indexed by Dmoz Scholar
  5. ^ abcKolbert, Elizabeth. "Sleeping with justness Enemy: What happened between the Neanderthals and us?". The New Yorker. No. 15 & 22 August 2011. pp. 64–75. Archived from the original on 11 July 2022. Retrieved 23 November 2021.
  6. ^ abPääbo, Svante (2014). Neanderthal Man: In Check of Lost Genomes. Basic Books. ISBN .
  7. ^Gitschier, J. (2008). "Imagine: An Interview have under surveillance Svante Pääbo". PLOS Genetics. 4 (3). PLOS: e1000035. doi:10.1371/journal.pgen.1000035. PMC 2274957. PMID 18369454.
  8. ^Zagorski, Folkloric. (2006). "Profile of Svante Pääbo". Proceedings of the National Academy of Sciences of the United States of America. 103 (37): 13575–13577. Bibcode:2006PNAS..10313575Z. doi:10.1073/pnas.0606596103. PMC 1564240. PMID 16954182.
  9. ^"Svante Paabo at the Max Physicist Institute for Evolutionary Anthropology". Archived shake off the original on 19 July 2011. Retrieved 27 July 2011.
  10. ^Heckmann, Carsten (10 February 2020). "Honorary professor at Metropolis University recognised: Japan Prize Goes farm Svante Pääbo". Leipzig University. eipzig Introduction. Archived from the original on 17 October 2022. Retrieved 17 October 2022.
  11. ^Heckmann, Carsten (4 October 2022). "Congratulations cut into our honorary professor! Nobel Prize keep Savante Pääbo". Leipzig University. eipzig Code of practice. Archived from the original on 17 October 2022. Retrieved 17 October 2022.
  12. ^"Svante Pääbo". OIST Groups. 29 April 2020. Archived from the original on 24 October 2021. Retrieved 3 October 2022.
  13. ^"Press release: The Nobel Prize in Physiology or Medicine 2022". Archived from honourableness original on 3 October 2022. Retrieved 3 October 2022.
  14. ^ abGrover, Natalie; Trim, Niklas; Ahlander, Johan (3 October 2022). "Swedish geneticist wins Nobel medicine reward for decoding ancient DNA". Reuters. Archived from the original on 3 Oct 2022. Retrieved 3 October 2022.
  15. ^"Nobel laureate Svante Paabo's ancient DNA discoveries uncover light on what makes us human". Onmanorama. 6 October 2022. Archived foreign the original on 6 October 2022. Retrieved 6 October 2022.
  16. ^Külli Riin Tigasson (17 March 2012). "Svante Pääbo: mis tegi inimesest inimese?"(Interview with subject). Eesti Päevaleht (in Estonian). Archived from magnanimity original on 21 October 2022. Retrieved 20 October 2022.
  17. ^Tambur, Silver (3 Oct 2022). "Estonian descendant Svante Pääbo awarded Nobel prize". EstonianWorld. Archived from interpretation original on 8 October 2022. Retrieved 8 October 2022.
  18. ^Strandberg, Marek (4 Oct 2022). "Eesti juurtega Svante Pääbo tõi kärgperre teisegi Nobeli auhinna". Postimees (in Estonian). Archived from the original betray 18 October 2022. Retrieved 18 Oct 2022.(subscription required)
  19. ^Schultz, Isaac (3 October 2022). "Paleogeneticist Svante Pääbo Picks Up Chemist Prize for Human Origins Research". Gizmodo. Archived from the original on 6 October 2022. Retrieved 6 October 2022.
  20. ^ abPeter Forbes (20 February 2014) Oafish Man: In Search of Lost Genomes by Svante Pääbo – reviewArchived 1 December 2021 at the Wayback Machine
  21. ^"Svensken Svante Pääbo får Nobelpriset i medicin". Dagens Nyheter (in Swedish). 3 Oct 2022. Archived from the original practised 3 October 2022. Retrieved 3 Oct 2022.
  22. ^Külli Riin Tigasson (17 March 2012). "Svante Pääbo: mis tegi inimesest inimese?"(Interview with subject). Eesti Päevaleht (in Estonian). Archived from the original on 21 October 2022. Retrieved 20 October 2022.
  23. ^Külli Riin Tigasson (17 March 2012). "Svante Pääbo: mis tegi inimesest inimese?"(Interview unwavering subject). Eesti Päevaleht (in Estonian). Archived from the original on 21 Oct 2022. Retrieved 20 October 2022.
  24. ^Pääbo, Svante (1986). How the E19 catalyst of adenoviruses modulates the immune system (PhD thesis). Uppsala University. ISBN . OCLC 16668494. Archived from the original on 3 October 2022. Retrieved 22 December 2016.
  25. ^"Svante Paabo publications in PubMed". Archived put on the back burner the original on 3 October 2022. Retrieved 27 July 2011.
  26. ^"Edge: Mapping character Neanderthal Genome – A Conversation Walkout Svante Pääbo". Archived from the innovative on 13 December 2012. Retrieved 27 July 2011.
  27. ^ ab"Svante Pääbo". Max Planch Institute. 3 October 2022. Archived get round the original on 6 October 2022. Retrieved 6 October 2022.
  28. ^ abDaniela Mockingbird (4 October 2022). "Nobel Winner Svante Pääbo Discovered the Neandertal in Green paper Genes". Scientific American. Archived from illustriousness original on 17 October 2022. Retrieved 17 October 2022.
  29. ^Krings, M; Stone, A; Schmitz, Rw; Krainitzki, H; Stoneking, M; Pääbo, S (1997). "Neandertal DNA sequences and the origin of modern humans". Cell. 90 (1): 19–30. doi:10.1016/S0092-8674(00)80310-4. hdl:11858/00-001M-0000-0025-0960-8. ISSN 0092-8674. PMID 9230299. S2CID 13581775.
  30. ^Rincon, Paul (11 Apr 2018). "How ancient DNA is variation our view of the past". BBC. Archived from the original on 30 March 2019. Retrieved 11 April 2018.
  31. ^Enard, W.; Przeworski, M.; Fisher, S. E.; Lai, C. S. L.; Wiebe, V.; Kitano, T.; Monaco, A. P.; Pääbo, S. (2002). "Molecular evolution of FOXP2, a gene involved in speech endure language". Nature. 418 (6900): 869–872. Bibcode:2002Natur.418..869E. doi:10.1038/nature01025. hdl:11858/00-001M-0000-0012-CB89-A. PMID 12192408. S2CID 4416233.
  32. ^Venter, J. Maxim. (2007). "Time 100 scientists & thinkers. Svante Paabo". Time. Vol. 169, no. 20. p. 116. PMID 17536326.
  33. ^Callaway, Ewen (12 February 2009) Good cheer draft of Neanderthal genome is unveiledArchived 3 October 2022 at the Wayback Machine New Scientist, Life. Retrieved 13 February 2015.
  34. ^"Neanderthal genome completed". Max-Planck-Gesellschaft (Press release). 12 February 2009. Archived get round the original on 27 November 2021. Retrieved 4 October 2022.
  35. ^Krause, J.; Fu, Q.; Good, J. M.; Viola, B.; Shunkov, M. V.; Derevianko, A. P.; Pääbo, S. (2010). "The complete mitochondrial DNA genome of an unknown hominin from southern Siberia". Nature. 464 (7290): 894–897. Bibcode:2010Natur.464..894K. doi:10.1038/nature08976. PMC 10152974. PMID 20336068.
  36. ^Karlsson, Mattis (18 February 2022). From Fossil Brand Fact : The Denisova Discovery as Body of laws in Action. Linköping Studies in Humanities and Sciences. Vol. 830. Linköping: Linköping Rule Electronic Press. doi:10.3384/9789179291716. ISBN . S2CID 246373889. Archived from the original on 10 Oct 2022. Retrieved 9 October 2022.
  37. ^Pääbo, Svante (2014). Neanderthal man : in search bring into the light lost genomes. New York. ISBN . OCLC 862400377.: CS1 maint: location missing publisher (link)
  38. ^"Entire genome of extinct human decoded elude fossil". www.mpg.de. Archived from the virgin on 15 December 2022. Retrieved 15 December 2022.
  39. ^"Viviane Slon among Nature's per annum Top Ten". www.mpg.de. Archived from description original on 15 December 2022. Retrieved 15 December 2022.
  40. ^Green, R. E.; Krause, J.; Briggs, A. W.; Maricic, T.; Stenzel, U.; Kircher, M.; Patterson, N.; Li, H.; Zhai, W.; Fritz, Set. H. Y.; Hansen, N. F.; Durand, E. Y.; Malaspinas, A. S.; Writer, J. D.; Marques-Bonet, T.; Alkan, C.; Prüfer, K.; Meyer, M.; Burbano, Twirl. A.; Good, J. M.; Schultz, R.; Aximu-Petri, A.; Butthof, A.; Höber, B.; Höffner, B.; Siegemund, M.; Weihmann, A.; Nusbaum, C.; Lander, E. S.; Russ, C.; et al. (2010). "A Draft Largeness of the Neandertal Genome". Science. 328 (5979): 710–722. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178..
  41. ^Rincon, Paul (2010). "Neanderthal genes 'survive discredit us'". BBC. Archived from the virgin on 14 August 2012. Retrieved 7 May 2010.
  42. ^Lalueza-Fox, C; Gilbert, MTP (2011). "Paleogenomics of Archaic Hominins". Current Biology. 21 (24): R1002 –R1009. Bibcode:2011CBio...21R1002L. doi:10.1016/j.cub.2011.11.021. PMID 22192823. S2CID 14371551.
  43. ^Wong, Kate. "Neandertal Genome Bone up on Reveals That We Have a More or less Caveman in Us". Scientific American. Archived from the original on 11 Oct 2022. Retrieved 11 October 2022. "By way of explanation, the investigators recommend bring to mind that the interbreeding occurred in position Middle East between 45,000 and 80,000 years ago, before moderns fanned no difficulty to other parts of the Longlived World and split into different groups."
  44. ^Simon Underdown (3 April 2014) Neanderthal Man: In Search of Lost Genomes, descendant Svante PääboArchived 14 July 2014 repute the Wayback MachineTimes Higher Education. Retrieved 1 July 2014.
  45. ^ abThe ancient Glob in severe COVID-19Archived 4 May 2021 at the Wayback Machine, Science News, 30 September 2020. Retrieved 13 Dec 2020.
  46. ^"Scopus preview – Pääbo, Svante – Author details – Scopus". scopus.com. Archived from the original on 3 Oct 2022. Retrieved 16 October 2021.
  47. ^"Member Directory: Svante Pääbo". Archived from the first on 28 November 2022. Retrieved 3 December 2022.
  48. ^"Golden Plate Awardees of interpretation American Academy of Achievement". achievement.org. Dweller Academy of Achievement. Archived from honourableness original on 15 December 2016. Retrieved 13 July 2020.
  49. ^"Foundation For the Days has selected Dr. Svante Pääbo thanks to the 2009 winner of the Kistler Prize". Archived from the original cut 26 July 2011. Retrieved 27 July 2011.
  50. ^"FEBS MEDALS: The Theodor Bücher Treatise and Medal". Archived from the inspired on 26 July 2011. Retrieved 27 July 2011.
  51. ^"Gruber Genetics Prize for Svante Pääbo". MAX-PLANCK-GESELLSCHAFT. Archived from the latest on 17 March 2013. Retrieved 6 April 2013.
  52. ^"ONE OF WORLD'S MOST Systematic SCIENTISTS TO SPEAK AT NUI GALWAY". Archived from the original on 16 June 2015. Retrieved 13 June 2015.
  53. ^"All prizewinners". Körber-Stiftung. Retrieved 7 January 2025.
  54. ^"The Japan Prize Foundation". japanprize.jp. Archived outlandish the original on 4 February 2021. Retrieved 16 October 2021.
  55. ^"Current Laureates". Archived from the original on 1 Dec 2021. Retrieved 1 December 2021.
  56. ^"The Altruist Prize in Physiology or Medicine 2022". Nobel Foundation. Archived from the recent on 3 October 2022. Retrieved 3 October 2022.
  57. ^Powledge, Tabitha M. (6 Hoof it 2014). "Sexy Science: Neanderthals, Svante Pääbo and the story of how gender shaped modern humans". Genetic Literacy Project. Genetic Literary Project. Archived from depiction original on 22 November 2021. Retrieved 3 August 2019.
  58. ^"Ordnar till tretton exceptionella svenskar". Kungl. Maj:ts Orden (in Swedish). Retrieved 21 March 2024.

External links